ILeVO (fluopyram) is a fungicide seed treatment for soybean sudden death syndrome (SDS) that also has nematicidal activity. ILeVO is sold with a base of insecticide Poncho (clothianidin), nematode-protectant VOTiVO (Bacillus firmus), and Acceleron fungicides (metalaxyl, fluxapyroxad, pyraclostrobin). Yield and reproduction of the soybean cyst nematode (Heterodera glycines; SCN) on soybeans grown from seed treated with ILeVO plus the base were compared to those treated with only the base in 27 small-plot experiments and 12 strip- trial experiments across Iowa from 2015 – 2017. To increase the likelihood that yield results were related to effects on SCN, data were used only from 26 small-plot experiments and 12 strip trials, those in which symptoms of SDS were low or nonexistent. An SCN reproductive factor (RF) was calculated for each experimental unit by dividing the SCN population density at harvest by the population density at planting. ILeVO significantly reduced SCN RF by 50 percent in one strip-trial experiment and by 36 percent to 60 percent in four small-plot experiments but yields were not increased by ILeVO in any of those five experiments. Soybean yields were 2.8 to 3.7 bu/ac (188.3 to 248.8 kg/ha) greater with ILeVO in three small-plot experiments, but SCN RF was not reduced in those experiments. Also, yield was 1.9 bu/ac (127.8 kg/ha) greater with ILeVO in one strip-trial experiment in 2016, but SCN samples were not collected at harvest from the study to assess the possible effects of ILeVO on SCN reproduction. When strip-trial data from 2015 and 2016 were combined, there was a small but significant 0.8 bu/ac (52.2 kg/ha) yield increase with ILeVO. Overall, the effects of Ilevo on SCN reproduction and soybean yield were variable in these field studies.