Soybean cyst nematode (SCN) is the most damaging pathogen of soybeans in the United States and is responsible for hundreds of millions of bushels in yield losses every year. Historically, nematicides have been used to manage economically important nematodes that affect crop production. However, soil-applied nematicides have not been used commonly to manage SCN due to their cost and lack of effectiveness. Nematode-protectant seed treatments have grown in availability and popularity since the mid 2000s, and they have varied modes of action. Many of these products contain biological control organisms or concentrated chemical compounds, making them ideal for use in sustainable production systems. Nematode-protectant seed treatments are intended to supplement current SCN management strategies, therefore should be used in coordination with growing varieties with SCN resistance genes and rotation to nonhost crops.