Article
Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers
Macromolecular Bioscience
(2013)
Abstract
There is an urgent need for new antibiotics which are effective against drug-resistant bacteria without contributing to resistance development. We have designed and developed antimicrobial copolymers with cationic amphiphilic structures based on the mimicry of naturally occurring antimicrobial peptides. These copolymers exhibit potent antimicrobial activity against a broad spectrum of bacteria including methicillin-resistant Staphylococcus aureus with no adverse hemolytic activity. Notably, these polymers also did not result in any measurable resistance development in E. coli. The peptide-mimetic design principle offers significant flexibility and diversity in the creation of new antimicrobial materials and their potential biomedical applications.
Disciplines
Publication Date
October, 2013
DOI
10.1002/mabi.201300126
Citation Information
Haruko Takahashi, Edmund F. Palermo, Kazuma Yasuhara, Gregory Caputo, et al.. "Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers" Macromolecular Bioscience Vol. 13 Iss. 10 (2013) p. 1285 - 1299 Available at: http://works.bepress.com/gregory-caputo/4/