Skip to main content
Randomized Clinical Trial to Evaluate the Pathogenicity of Bibersteinia trehalosi in Respiratory Disease among Calves
BMC Veterinary Research
  • Christy Jo Hanthorn, Iowa State University
  • Reneé Dewell, Iowa State University
  • Vickie L. Cooper, Iowa State University
  • Timothy S. Frana, Iowa State University
  • Paul J. Plummer, Iowa State University
  • Chong Wang, Iowa State University
  • Grant A. Dewell, Iowa State University
Document Type
Publication Version
Published Version
Publication Date

Bibersteinia trehalosi causes respiratory disease in ruminants particularly in wild and domestic sheep. Recently, there has been an increased number of B. trehalosi isolates obtained from diagnostic samples from bovine respiratory disease cases. This study evaluated the role of B. trehalosi in bovine respiratory disease using an intra-tracheal inoculation model in calves. Thirty six cross bred 2–3 month old dairy calves were inoculated intra-tracheally with either leukotoxin negative B. trehalosi, leukotoxin positive B. trehalosi isolate, Mannheimia haemolytica, a combination of leukotoxin negative B. trehalosi and M. haemolytica or negative control. Calves were euthanized and necropsy performed on day 10 of study. B. trehalosi inoculated calves did not have increased lung involvement compared to control calves. Additionally, B. trehalosiwas only cultured once from the lungs of inoculated calves at necropsy. Based on these findings B. trehalosi may not be a primary pathogen of respiratory disease in cattle. Culture of B. trehalosifrom diagnostic submissions should not be immediately identified as a primary cause of respiratory disease.


This article is from BMC Veterinary Research 10 (2014): 89, doi:10.1186/1746-6148-10-89. Posted with permission.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright Owner
Christy J. Hanthorn, et al
File Format
Citation Information
Christy Jo Hanthorn, Reneé Dewell, Vickie L. Cooper, Timothy S. Frana, et al.. "Randomized Clinical Trial to Evaluate the Pathogenicity of Bibersteinia trehalosi in Respiratory Disease among Calves" BMC Veterinary Research Vol. 10 (2014) p. 1 - 8
Available at: