The progesterone receptor Val660→Leu polymorphism and breast cancer riskBreast Cancer Research (2004)
AbstractBackground Recent evidence suggests a role for progesterone in breast cancer development and tumorigenesis. Progesterone exerts its effect on target cells by interacting with its receptor; thus, genetic variations, which might cause alterations in the biological function in the progesterone receptor (PGR), can potentially contribute to an individual's susceptibility to breast cancer. It has been reported that the PROGINS allele, which is in complete linkage disequilibrium with a missense substitution in exon 4 (G/T, valine→leucine, at codon 660), is associated with a decreased risk for breast cancer. Methods Using a nested case-control study design within the Nurses' Health Study cohort, we genotyped 1252 cases and 1660 matched controls with the use of the Taqman assay. Results We did not observe any association of breast cancer risk with carrying the G/T (Val660→Leu) polymorphism (odds ratio 1.10, 95% confidence interval 0.93–1.30). In addition, we did not observe an interaction between this allele and menopausal status and family history of breast cancer as reported previously. Conclusion Overall, our study does not support an association between the Val660→Leu PROGINS polymorphism and breast cancer risk.
- breast cancer,
- linkage disequilibrium,
- progesterone receptor
Publication DateSeptember 22, 2004
Citation InformationImmaculata De Vivo, Susan E. Hankinson, Graham A. Colditz and David J. Hunter. "The progesterone receptor Val660→Leu polymorphism and breast cancer risk" Breast Cancer Research Vol. 6 (2004)
Available at: http://works.bepress.com/graham_colditz/11/