Stress is a concern of college students as they are encountered with a variety of academic, financial, and social pressures. Psychosocial stress is associated with an increased risk of coronary heart disease, which is partially related to stress-induced endothelial dysfunction. “Endothelial dysfunction” has been associated not only with hypertension or atherosclerosis, but also with physiological and pathophysiological processes including aging, smoking and stress. It was found that music might stimulate the β-endorphin to activate endothelium-derived nitric oxide in vessel dilation. Music might induce positive emotions and beneficially influence vascular health. Increasing the awareness of the impacts of stress-induced anxiety on endothelium related to the risk of cardiovascular diseases may make a difference in the lives of college students.