|2013 ‐ Present||Professor, Nova Southeastern University ‐ College of Psychology|
|1994||Ph.D., Chemical Engineering, Ecole Polytechnique de Montreal|
|1989||M.Eng., Chemical Engineering, McGill University|
|1984||B.Eng., Mechanical Engineering, McGill University|
Journal articles written or co-written by Dr. Gordon Broderick
Achieving Remission in Gulf War Illness: A Simulation-Based Approach to Treatment Design PLos ONE (2015)
Gulf War Illness (GWI) is a chronic multi-symptom disorder affecting up to one-third of the 700,000 returning veterans of the 1991 Persian Gulf War and for which there is no known cure. GWI symptoms span ...
Inferring Broad Regulatory Biology from Time Course Data: Have We Reached an Upper Bound under Constraints Typical of In Vivo Studies? PLos ONE (2015)
There is a growing appreciation for the network biology that regulates the coordinated expression of molecular and cellular markers however questions persist regarding the identifiability of these networks. Here we explore some of the issues ...
Using gene expression signatures to identify novel treatment strategies in gulf war illness BMC medical genomics (2015)
Background Gulf War Illness (GWI) is a complex multi-symptom disorder that affects up to one in three veterans of this 1991 conflict and for which no effective treatment has been found. Discovering novel treatment strategies ...
A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome PLoS ONE (2014)
A key component in the body's stress response, the hypothalamic-pituitary-adrenal (HPA) axis orchestrates changes across a broad range of major biological systems. Its dysfunction has been associated with numerous chronic diseases including Gulf War Illness ...
Alteredimmune pathway activity under exercise challenge in Gulf War Illness: An exploratory analysis Brain, Behavior, and Immunity (2013)
Though potentially linked to the basic physiology of stress response we still have no clear understanding of Gulf War Illness (GWI), a debilitating illness presenting with a complex constellation of immune, endocrine and neurological symptoms. ...
Succumbing to the Laws of Attraction: Exploring the Sometimes Pathogenic Versatility of Discrete Immune Logic Systems Biomedicine (2013)
Feedback mechanisms throughout the immune and endocrine systems play a significant role in maintaining physiological homeostasis. Specifically, the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes contribute important oversight of immune activity and homeostatic regulation. We propose ...
Cytokine Expression Profiles of Immune Imbalance in Postmononucleosis Chronic Fatigue ComPlexUs (2012)
Background As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections; our objective was to describe differences in immune activation in post-infective CFS (PI-CFS) patients and recovered controls. ...
Systems Biology of Complex Symptom Profiles: Capturing Interactivity across Behavior, Brain and Immune Regulation Systems Biomedicine (2012)
As our thinking about the basic principles of biology and medicine continue to evolve, the importance of context and regulatory interaction is becoming increasingly obvious. Biochemical and physiological components do not exist in isolation but ...
Using an agent-based model to analyze the dynamic communication network of the immune response Journal of Translational Medicine (2011)
BACKGROUND: The immune system behaves like a complex, dynamic network with interacting elements including leukocytes, cytokines, and chemokines. While the immune system is broadly distributed, leukocytes must communicate effectively to respond to a pathological challenge. ...
Biomarkers in chronic fatigue syndrome: Evaluation of natural killer cell function and dipeptyl peptidase IV. Clinical and Vaccine Immunology (2010)
BACKGROUND: Chronic Fatigue Syndrome (CFS) studies from our laboratory and others described decreased natural killer cell cytotoxicity (NKCC) and elevated proportion of lymphocytes expressing the activation marker, dipeptidyl peptidase IV (DPPIV) also known as CD26. ...