We analyze the spillovers of Western economic sanctions against Russia into twenty-seven transition economies of the former Soviet Union, and Central and Eastern Europe. These spillovers are measured in terms of their impact on bilateral trade and direct investments for the period of 2014–2018. We construct a new dataset to quantify each episode of Western/US sanctions against Russia. The gravity models of bilateral trade and direct investment are used and the data analysis is conducted using Poisson pseudo-maximum likelihood econometric technique. We estimate that the Western and U.S. sanctions against Russia spilled over into third-party small countries. These sanctions resulted in the significant decline of exports from transition economies, Russian imports to transition economies, and Russian direct investments to transition economies. Interestingly, the direct investments to Russia from transition economies sharply increased during the same period. The quantitative estimates of the spillovers suggest the following cumulative changes. Due to an imposed sanction type (e.g., against an individual, entity or sector) each episode of Western/U.S. sanction resulted in the decline of aforementioned indicators in the range of 10.9–30.5-million-dollar/5.6–16.9-million-dollar of exports from transition economies, 6.3–17.7-million-dollar/3.3–9.8-million-dollar of Russian imports to transition economies, and 3.4–9.4-million-dollar/1.7–5.2-million-dollar of Russian direct investments to transition economies. The direct investments to Russia from transition economies increased by 10.9–30.6-million-dollar/5.7–17-million-dollar, respectively.