Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent studies focus attention on progenitor cells as major targets. The results suggest new biomarkers that may improve risk prediction and provide endpoints for assessment of clinical responses to prophylactic therapies.
Pregnancy offers new insights into mechanisms of breast cancer risk and resistanceAll Scholarly Works
Document TypeArticle, Peer-reviewed
Citation InformationJerry DJ, Makari-Judson G, Crisi GM, Dunphy KA. Pregnancy offers new insights into mechanisms of breast cancer risk and resistance. Breast Cancer Res. 2013 Sep 24;15(5):312.