"Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC." by Giovanna Crisi, MD

Article

Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC.

All Scholarly Works

Giovanna Crisi, MD, Baystate Health

Document Type

Article, Peer-reviewed

Publication Date

10-1-2005

Abstract

Dendritic cells (DC), uniquely among APC, express an open/empty conformation of MHC class II (MHC-II) proteins (correctly folded molecules lacking bound peptides). Generation and trafficking of empty HLA-DR during DC differentiation are investigated here.

Publication ISSN

0884-8734

Citation Information

J Immunol 2005 Oct 15;175(8):4935-47.