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Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC.
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  • Giovanna Crisi, MD, Baystate Health
Document Type
Article, Peer-reviewed
Publication Date
Dendritic cells (DC), uniquely among APC, express an open/empty conformation of MHC class II (MHC-II) proteins (correctly folded molecules lacking bound peptides). Generation and trafficking of empty HLA-DR during DC differentiation are investigated here.
Publication ISSN
Citation Information
J Immunol 2005 Oct 15;175(8):4935-47.