Dendritic cells (DC), uniquely among APC, express an open/empty conformation of MHC class II (MHC-II) proteins (correctly folded molecules lacking bound peptides). Generation and trafficking of empty HLA-DR during DC differentiation are investigated here.
Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC.All Scholarly Works
Document TypeArticle, Peer-reviewed
Citation InformationJ Immunol 2005 Oct 15;175(8):4935-47.