SelectedWorks - Giovanna Crisi MD

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Selected Works of Giovanna Crisi MD

Pathology, Medical Director, Renal, Electron Microscopy and Breast Pathology

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About Giovanna Crisi MD

Present	Associate Professor of Pathology, Tufts University School of Medicine
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution
Present	Pathology, Medical Director, Renal, Electron Microscopy and Breast Pathology, Baystate Health
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Medicine and Health Sciences

Baystate Education and Research

759 Chestnut Street
Springfield, MA 01199

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Interindividual variation contributes to differential PCB 126 induced gene expression in primary breast epithelial cells and tissues (Stephanie M Morin, Giovanna Crisi, Kelly Gregory, et al.) All Scholarly Works (2022)

PCB 126 is a pervasive, dioxin-like chemical pollutant which can activate the aryl hydrocarbon receptor (AhR). Despite being banned from the market, PCB 126 can be detected in breast milk to this day. The extent ...

Intraoperative Lymph Node Assessment (Touch Preparation Only) for Metastatic Breast Carcinoma in Neoadjuvant and Non-neoadjuvant Settings (Esma Ersoy, Mahmoud Elsayad, Madhavi Pandiri, et al.) All Scholarly Works (2022)

Context.—: Touch preparation (TP) alone is discouraged for intraoperative lymph node (LN) assessment in the neoadjuvant setting (NAS) owing to overall low sensitivity in detecting metastatic breast cancer. Objective.—: To compare the sensitivity, specificity, and ...

Syringomatous adenoma of the nipple with microcalcifications on mammography: A case report (Shiva Niakan, Angelica Patino, Nupur Jadhav, et al.) All Scholarly Works (2020)

Syringomatous adenoma of the nipple (SAN) is a rare benign lesion which often presents as a subareolar mass with associated nipple shape changes including pruritus, crusting, and discharge It is thought that syringomatous tumors arise ...

Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization (Kelly Gregory, Sallie Schneider, Giovanna Crisi, et al.) All Scholarly Works (2020)

While changes in DNA methylation are known to occur early in breast carcinogenesis and the landscape of breast tumour DNA methylation is profoundly altered compared with normal tissue, there have been limited efforts to identify ...

Inter-Individual Variation in Response to Estrogen in Human Breast Explants (Jennifer Ser-Dolansky, Sallie Schneider, Grace Makari-Judson, et al.) All Scholarly Works (2020)

Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive ...

Gene expression signature of atypical breast hyperplasia and regulation by SFRP1 (Kelly Gregory, Giovanna Crisi, Brooke Bentley, et al.) All Scholarly Works (2019)

BACKGROUND: Atypical breast hyperplasias (AH) have a 10-year risk of progression to invasive cancer estimated at 4-7%, with the overall risk of developing breast cancer increased by ~ 4-fold. AH lesions are estrogen receptor alpha ...

Individual-specific Variation in the Respiratory Activities of HMECs and Their Bioenergetic Response to IGF1 and TNFα (Sallie Schneider, Elizabeth Henchey, Nazeen Sultana, et al.) All Scholarly Works (2017)

Metabolic reprograming is a hallmark of cancer cells. However, the roles of pre-existing differences in normal cells metabolism toward cancer risk is not known. In order to assess pre- existing variations in normal cell metabolism, ...

Evaluation of PolyMPC-Dox Prodrugs in a Human Ovarian Tumor Model (Kaitlyn Wong, Maria Carmen Mora, Giovanna Crisi, et al.) All Scholarly Works (2016)

A polymer prodrug, composed of doxorubicin (Dox) conjugated covalently to poly(methacryloyloxyethyl phosphorylcholine) (polyMPC), was evaluated for the treatment of human ovarian tumors in animals. PolyMPC-Dox prodrugs were prepared using facile conjugation chemistry to yield conjugates ...

Antineoplastic effects of Rhodiola crenulata treatment on B16-F10 melanoma (Kaitlyn Wong, Lotfi Bassa, Maria Carmen Mora, et al.) All Scholarly Works (2015)

Melanoma is an aggressive form of skin cancer with limited treatment options for advanced stage disease. Early detection and wide surgical excision remain the initial mode of treatment for primary tumors thus preventing metastases and ...

Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers (Sallie Smith-Schneider, Sharon Marconi, Christopher Otis, et al.) All Scholarly Works (2012)

BACKGROUND: Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and its major splice variant (Δ exon ...

Gene Expression Profiles Identify Features Common to Lobular and Ductal Premalignant Breast Lesions (Amy L. Roberts, D. Joseph Jerry, Kelly J. Gauger, et al.) UMass Center for Clinical and Translational Science Research Symposium (2014)

Premalignant lesions have been identified in both the ductal and lobular units of the breast epithelium. These lesions have a 4-fold increase in risk of progression to invasive breast cancer, but 80% will remain indolent. ...

Diagnostic evaluation of the augmented breast (Jane An, Jennifer Hadro, David March, et al.) All Scholarly Works (2013)

Pregnancy offers new insights into mechanisms of breast cancer risk and resistance (D. Joseph Jerry, Grace Makari-Judson, Giovanna Crisi, et al.) All Scholarly Works (2013)

Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent ...

Immunolocalization of the calcium-sensing receptor in developing human kidney (Giovanna Crisi, Gary Rockwell, Gregory Braden, et al.) All Scholarly Works (2013)

Background:The calcium-sensing receptor (CSR) is a G-protein receptor that plays a critical role in calcium regulation. In the kidney, the CSR regulates calcium reabsorption in the thick ascending limb, where stimulation of the CSR inhibits ...

Detecting cancers in dense tissue on screening mammography (Jane An, Jennifer Hadro, David March, et al.) All Scholarly Works (2013)

Oncogenic Transformation of Mammary Epithelial Cells by Transforming Growth Factor Beta Independent of Mammary Stem Cell Regulation (Karen A Dunphy, Jae-Hong Seo, Daniel J Kim, et al.) Cancer Cell International (2013)

Background: Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland during involution and by radiation. While TGFβ normally has a tumour suppressor role, prolonged exposure to TGFβ can induce an oncogenic epithelial ...

Loss of SFRP1 promotes ductal branching in the murine mammary gland (Kelly Gauger, Giovanna Crisi and Sallie Schneider) All Scholarly Works (2012)

BACKGROUND: Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of SFRP1 expression is found in breast cancer along with a multitude of other human cancers. Activated ...

Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers (Casey M. Turk, Katerina D. Fagan-Solis, Kristin E. Williams, et al.) Cancer Cell International (2012)

Background Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and its major splice variant (Δ exon ...

Renal sarcoidosis presenting as acute kidney injury with granulomatous interstitial nephritis and vasculitis (Varun Agrawal, Giovanna Crisi and Benjamin Freda) All Scholarly Works (2012)

Among the various renal manifestations of sarcoidosis, granulomatous inflammation confined to the tubulointerstitial compartment is the most commonly reported finding. We present the case of a 66-year-old man with acute kidney injury, hypercalcemia, mild restrictive ...

Mediators of the inflammatory response to joint replacement devices (Giovanna Crisi) All Scholarly Works (2011)

Joint replacement surgery is one of the success stories of modern medicine, restoring mobility, diminishing pain and improving the overall quality of life for millions of people. Unfortunately, wear of these prostheses over time generates ...

Spectrum of breast disease encountered in HIV-positive patients at a community teaching hospital (Liron Pantanowitz, Sabyasachi Sen, Giovanna Crisi, et al.) All Scholarly Works (2011)

INTRODUCTION: HIV infection directly and indirectly affects breast tissue. This study describes the spectrum of HIV-related breast disease encountered at a community teaching hospital. METHODS: A 9 year retrospective review was performed of HIV-positive patients ...

Electron microscopy in end stage renal disease: a case of Fabry's disease (Giovanna Crisi, Adriana Doldan-Silvero and Michael Germain) All Scholarly Works (2010)

Fabry's disease is an X-linked error of metabolism with deficiency of the enzyme α-glycosidase A, and glycosphingolipid accumulation in multiple tissues. Patients may be asymptomatic and present with advanced disease. We report a case of ...

Mastocytosis of the female breast (Giovanna Crisi, Liron Pantanowitz and Namrata Setia) All Scholarly Works (2010)

A subset of patients with systemic mastocytosis may manifest with extracutaneous involvement. To the best of our knowledge, mastocytosis of the human breast has not been described. This study reports a case with mastocytosis involving ...

Microtumor embolization leading to cor pulmonale: an extremely rare complication of ovarian cancer (Giovanna Crisi and Ranjit Dhelaria) All Scholarly Works (2010)