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Article
A mandatory single blastocyst transfer policy with educational campaign in a United States IVF program reduces multiple gestation rates without sacrificing pregnancy rates
Fertility and sterility
  • Ginny L. Ryan, University of Iowa
  • Amy E.T. Sparks, University of Iowa
  • C. S. Sipe
  • Craig H. Syrop, University of Iowa
  • A. Dokras
  • Bradley J. Van Voorhis, University of Iowa
Document Type
Article
Peer Reviewed
1
Publication Date
8-1-2007
NLM Title Abbreviation
Fertil Steril
PubMed ID
17490657
DOI of Published Version
10.1016/j.fertnstert.2007.03.001
Abstract

OBJECTIVE: To reduce the twin rate in our IVF program. DESIGN: A prospective educational study of infertile couples; a retrospective review of IVF outcomes before vs. after mandatory single embryo transfer (mSBT) policy change. SETTING: University-based infertility center. PATIENT(S): One hundred ten of 120 consecutive new infertile couples completed the educational study. Outcomes of all embryo transfers (n = 693) performed 17 months before and 17 months after mSBT were evaluated. INTERVENTION(S): A 1-page educational summary of comparative risks of twins vs. singletons to maternal and child health. MAIN OUTCOME MEASURE(S): Knowledge of twin risks and desired number of embryos transferred before and after education. Pregnancy rates, number of embryos transferred, and multiple-gestation rates before and after mSBT policy. RESULT(S): After education, knowledge of twin risks improved and a significant number of subjects changed their desired outcome to a lower gestational number. There was no change in ongoing pregnancy rates with blastocyst transfer before and after mSBT (63% vs. 58%; NS). Program-wide number of embryos transferred (2.1 +/- 0.6 vs. 1.9 +/- 0.7) and multiple-gestation rates (35% vs. 19%) decreased significantly while pregnancy rates were maintained. CONCLUSION(S): Simple educational materials can improve knowledge of twin pregnancy risks and affect decision making. In high-risk patients, mSBT results in pregnancy rates similar to two-blastocyst transfer, with decreased twin rates.

Keywords
  • Adult,
  • Cell Count,
  • Embryo Transfer,
  • Female,
  • Fertilization in Vitro/legislation & jurisprudence,
  • Health Knowledge,
  • Attitudes,
  • Practice,
  • Humans,
  • Male,
  • Patient Education as Topic,
  • Patient Satisfaction,
  • Pregnancy,
  • Pregnancy Rate,
  • Pregnancy,
  • Multiple/statistics & numerical data,
  • Twins,
  • United States
Published Article/Book Citation
Fertility and sterility, 88:2 (2007) pp.354-360.
Citation Information
Ginny L. Ryan, Amy E.T. Sparks, C. S. Sipe, Craig H. Syrop, et al.. "A mandatory single blastocyst transfer policy with educational campaign in a United States IVF program reduces multiple gestation rates without sacrificing pregnancy rates" Fertility and sterility Vol. 88 Iss. 2 (2007) p. 354 - 360 ISSN: 1556-5653
Available at: http://works.bepress.com/ginny_ryan/13/