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Article
Considering a New Paradigm for Alzheimer’s Disease Research
EXP
  • Gillian R. Langley
Document Type
Article
Publication Date
8-1-2014
Abstract
Using Alzheimer’s disease as a case study, this review argues that it might be time to consider a new paradigm in medical research and drug discovery. The existing framework is overly dependent on often unvalidated animal models, particularly transgenic mice. Translational success remains elusive and costly late-stage drug failure is common. The conventional paradigm tends to overlook species differences and assumes that animal-based findings are generally applicable to humans. Could pathways-based research using advanced human-specific models probed with new tools, including those of systems biology, take centre stage? The current transition in chemical toxicology to a 21st-century paradigm could be a model for health research, with probable medical and economic benefits.
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Citation Information
Langley, G. R. (2014). Considering a new paradigm for Alzheimer's disease research. Drug discovery today, 19(8), 1114-1124.