A vast majority of academic disciplines and curricula in the college center around science, technology, engineering, and mathematics (STEM), which are critical to developing the skills necessary for a global workforce. Rapid changes in the pedagogical frameworks, educational modes, and advances in instructional technology entail diverse challenges for key stakeholders (i.e. students, faculty, and the organizations). This presentation highlights the most relevant challenges and potential solutions in STEM higher education. The comprehensive analysis of the three stakeholders’ perspectives elucidates significant contemporary aspects impacting the fields. The goal is to further understand the factors impeding expected learning outcomes. This would help identify as well as bridge the gaps among these three pillars of instruction, possibly forming a foundation for improved content, delivery, and efficacy of higher education in STEM.