Article
One-Pot Synthesis of 2-Substituted Indoles from 2-Aminobenzyl Phosphonium Salts. A Formal Total Synthesis of Arcyriacyanin A
Organic Letters
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
6-24-2008
DOI
10.1021/ol801034x
Abstract
The reaction of (2-aminobenzyl) triphenylphosphonium bromide with aromatic aldehydes or α,β-unsaturated aldehydes under microwave-assisted conditions constitutes a new synthesis of 2-substituted indoles in high yields (81−97%) in a one-pot reaction. The adduct from indole-4-carboxaldehyde was an advanced intermediate in the synthesis of arcyriacyanin A.
Copyright Owner
American Chemical Society
Copyright Date
2008
Language
en
File Format
application/pdf
Citation Information
George A. Kraus and Haitao Guo. "One-Pot Synthesis of 2-Substituted Indoles from 2-Aminobenzyl Phosphonium Salts. A Formal Total Synthesis of Arcyriacyanin A" Organic Letters Vol. 10 Iss. 14 (2008) p. 3061 - 3063 Available at: http://works.bepress.com/george_kraus/76/
Reprinted (adapted) with permission from Organic Letters, 10(14); 3061-3063. Doi: 10.1021/ol801034x. Copyright 2008 American Chemical Society.