Skip to main content
Article
Michael additions in anhydrous media. A novel synthesis of oxygenated coumarins
The Journal of Organic Chemistry
  • George A. Kraus, Iowa State University
  • John O. Pezzanite, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
7-1-1979
DOI
10.1021/jo01328a031
Abstract

A general procedure is described where an aryllithium, generated by metalation of a protected phenol with n-butyllithium, adds in a conjugate manner to diethyl ethoxymethylenemalonate to give after acid hydrolysis an oxygenated 3-carbethoxycoumarin. By this procedure the ethyl vinyl ethers 9, 11, 13, and 15 are converted into the corresponding coumarins 10, 12, 14, and 16 in a single reaction vessel in good yield.

Comments

Reprinted (adapted) with permission from The Journal of Organic Chemistry, 44(14); 2480-2482. Doi: 10.1021/jo01328a031. Copyright 1979 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
George A. Kraus and John O. Pezzanite. "Michael additions in anhydrous media. A novel synthesis of oxygenated coumarins" The Journal of Organic Chemistry Vol. 44 Iss. 14 (1979) p. 2480 - 2482
Available at: http://works.bepress.com/george_kraus/75/