Michael additions in anhydrous media. A novel synthesis of oxygenated coumarinsThe Journal of Organic Chemistry
Publication VersionPublished Version
AbstractA general procedure is described where an aryllithium, generated by metalation of a protected phenol with n-butyllithium, adds in a conjugate manner to diethyl ethoxymethylenemalonate to give after acid hydrolysis an oxygenated 3-carbethoxycoumarin. By this procedure the ethyl vinyl ethers 9, 11, 13, and 15 are converted into the corresponding coumarins 10, 12, 14, and 16 in a single reaction vessel in good yield.
Copyright OwnerAmerican Chemical Society
Citation InformationGeorge A. Kraus and John O. Pezzanite. "Michael additions in anhydrous media. A novel synthesis of oxygenated coumarins" The Journal of Organic Chemistry Vol. 44 Iss. 14 (1979) p. 2480 - 2482
Available at: http://works.bepress.com/george_kraus/75/