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Deprotonation of Benzylic Ethers Using a Hindered Phosphazene Base. A Synthesis of Benzofurans from Ortho-Substituted Benzaldehydes
Organic Letters
  • George A. Kraus, Iowa State University
  • Ning Zhang, Iowa State University
  • John G. Verkade, Iowa State University
  • Muthukaman Nagarajan, Iowa State University
  • Philip B. Kisanga, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
7-13-2000
DOI
10.1021/ol0000758
Abstract

The hindered nonionic phosphazene base P4-t-Bu efficiently deprotonates o-arylmethoxy benzaldehydes, leading to a direct synthesis of benzofurans. Strong ionic bases such as LDA, LiTMP, and KH failed.

Comments

Reprinted (adapted) with permission from Organic Letters, 2(16); 2409-2410. Doi: 10.1021/ol0000758. Copyright 2000 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
George A. Kraus, Ning Zhang, John G. Verkade, Muthukaman Nagarajan, et al.. "Deprotonation of Benzylic Ethers Using a Hindered Phosphazene Base. A Synthesis of Benzofurans from Ortho-Substituted Benzaldehydes" Organic Letters Vol. 2 Iss. 16 (2000) p. 2409 - 2410
Available at: http://works.bepress.com/george_kraus/42/