A direct synthesis of racemic demethoxyaflatoxin B2
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1991-09-01
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Kraus, George
University Professor Emeritus
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Chemistry
Abstract
Aflatoxin analogue 19 was prepared by a direct sequence involving a novel silver-mediated cyclization to 12, the Michael addition of 16 with 17, and the oxidation of the Michael addition adduct. The overall yield of this six-step route is approximately 11%. The pathway is a flexible one that will permit the synthesis of analogues for toxicological analysis.
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Reprinted (adapted) with permission from The Journal of Organic Chemistry, 56(19); 5688-5691. Doi: 10.1021/jo00019a042. Copyright 1991 American Chemical Society.
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Tue Jan 01 00:00:00 UTC 1991