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Article
A direct synthesis of racemic demethoxyaflatoxin B2
The Journal of Organic Chemistry
  • George A. Kraus, Iowa State University
  • Beth E. Johnston, Iowa State University
  • Jacqueline M. Applegate, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
9-1-1991
DOI
10.1021/jo00019a042
Abstract
Aflatoxin analogue 19 was prepared by a direct sequence involving a novel silver-mediated cyclization to 12, the Michael addition of 16 with 17, and the oxidation of the Michael addition adduct. The overall yield of this six-step route is approximately 11%. The pathway is a flexible one that will permit the synthesis of analogues for toxicological analysis.
Comments

Reprinted (adapted) with permission from The Journal of Organic Chemistry, 56(19); 5688-5691. Doi: 10.1021/jo00019a042. Copyright 1991 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
George A. Kraus, Beth E. Johnston and Jacqueline M. Applegate. "A direct synthesis of racemic demethoxyaflatoxin B2" The Journal of Organic Chemistry Vol. 56 Iss. 19 (1991) p. 5688 - 5691
Available at: http://works.bepress.com/george_kraus/24/