Article
Efficient synthesis of fluorescent rosamines: multifunctional platforms for cellular imaging
Tetrahedron Letters
Document Type
Article
Disciplines
Publication Version
Accepted Manuscript
Publication Date
2-26-2014
DOI
10.1016/j.tetlet.2014.01.067
Abstract
Substituted rosamines are efficiently prepared through a new organometallic addition to an imine-substituted xanthone as a novel primary amine equivalent. The synthesis reduces the number of synthetic steps to the targeted rosamines, for convenient and facile access to potential libraries of rosamine dyes. The prepared rosamine derivatives represent unique multifunctional platforms that possess radiolabeling capability and fluorescence. Rosamines have (i) useful non-specific binding properties in mammalian cells and plant root hair, and (ii) positive uptake or binding properties in microbial systems.
Creative Commons License
Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International
Copyright Owner
Elsevier Ltd.
Copyright Date
2014
Language
en
File Format
application/pdf
Citation Information
George A. Kraus, Tezcan Guney, Aaron Kempema, Joel M. Hyman, et al.. "Efficient synthesis of fluorescent rosamines: multifunctional platforms for cellular imaging" Tetrahedron Letters Vol. 55 Iss. 9 (2014) p. 1549 - 1551 Available at: http://works.bepress.com/george_kraus/235/
This is a manuscript of an article published as Kraus, George A., Tezcan Guney, Aaron Kempema, Joel M. Hyman, and Bahram Parvin. "Efficient synthesis of fluorescent rosamines: multifunctional platforms for cellular imaging." Tetrahedron Letters 55, no. 9 (2014): 1549-1551. DOI: 10.1016/j.tetlet.2014.01.067. Posted with permission.