Synthesis of novel 6-deoxyanthracyclinesThe Journal of Organic Chemistry
Publication VersionPublished Version
AbstractAn extremely direct route to the 6-deoxyanthracycline skeleton is described. The initial route to quinone 10 failed due to an unexpected complication in the Ago demethylation step. However, starting from 2-bromo- 1,4-dimethoxynaphthalene, furan 17 could be prepared in two steps. Furan 17 was then converted into anthraquinone 19 in five steps. The eight-step route proceeds in 9% overall yield.
Copyright OwnerAmerican Chemical Society
Citation InformationGeorge A. Kraus and Michael D. Hagen. "Synthesis of novel 6-deoxyanthracyclines" The Journal of Organic Chemistry Vol. 50 Iss. 18 (1985) p. 3252 - 3255
Available at: http://works.bepress.com/george_kraus/199/