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Article
Stereoselective synthesis of calonectrin
Journal of The American Chemical Society
  • George A. Kraus, Iowa State University
  • Bruce Roth, Iowa State University
  • Kevin Frazier, Iowa State University
  • Masayuki Shimagaki, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
2-1-1982
DOI
10.1021/ja00368a043
Abstract

Several macrocyclic lactones of the trichothecene class of compounds exhibit significant anticancer activity.' A common structural subunit in each of these lactones is the sesquiterpene verrucarol(1). Anguidin (2), a more highly oxygenated analogue, also shows inhibitory activity against several cancers., Calonectrin (3), considered to be the biogenetic precursor to verru~arol,~ has recently been isolated.

Comments

Reprinted (adapted) with permission from Journal of the American Chemical Society,104(4); 1114-1116. Doi: 10.1021/ja00368a043. Copyright 1982 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
George A. Kraus, Bruce Roth, Kevin Frazier and Masayuki Shimagaki. "Stereoselective synthesis of calonectrin" Journal of The American Chemical Society Vol. 104 Iss. 4 (1982) p. 1114 - 1116
Available at: http://works.bepress.com/george_kraus/179/