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Article
Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
Molecules
  • George A. Kraus, Iowa State University
  • Insik Jeon, Iowa State University
  • Marit Nilsen-Hamilton, Iowa State University
  • Ahmed M. Awad, Iowa State University
  • Jayeeta Banerjee, Iowa State University
  • Bahram Parvin, Lawrence Berkeley Laboratory
Document Type
Article
Publication Version
Published Version
Publication Date
4-27-2008
DOI
10.3390/molecules13040986
Abstract
A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.
Comments

Reprinted (adapted) with permission from Molecules, 2008; 13(4); 986-994. Doi: 10.3390/molecules13040986. Posted with permission.

Copyright Owner
MDPI AG
Language
en
File Format
application/pdf
Citation Information
George A. Kraus, Insik Jeon, Marit Nilsen-Hamilton, Ahmed M. Awad, et al.. "Fluorinated Analogs of Malachite Green: Synthesis and Toxicity" Molecules Vol. 13 Iss. 4 (2008) p. 986 - 94
Available at: http://works.bepress.com/george_kraus/151/