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Article
Facile synthesis of N-acyl-2-pyrrolines
The Journal of Organic Chemistry
  • George A. Kraus, Iowa State University
  • Kent Neuenschwander, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
11-1-1981
DOI
10.1021/jo00336a036
Abstract

In conjunction with our studies of the amidoalkylation reaction,' multigram quantities of N-acyl-2-pyrrolines (1) were needed. Interestingly, only a few methods for the synthesis of this class of compounds had been reported. Stille and co-workers prepared 1 by a novel transition metal mediated isomerization of N-acyl-3-pyrrolines2 and also cyclized (acy1amino)butyraldehydes to produce le3 Although these methods are excellent for qmall-scale preparation, large-scale reactions would entail considerable expense.

Comments

Reprinted (adapted) with permission from The Journal of Organic Chemistry,46(23); 4791-4792. Doi: 10.1021/jo00336a036. Copyright 1981 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
George A. Kraus and Kent Neuenschwander. "Facile synthesis of N-acyl-2-pyrrolines" The Journal of Organic Chemistry Vol. 46 Iss. 23 (1981) p. 4791 - 4792
Available at: http://works.bepress.com/george_kraus/147/