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Article
Conversion of lactones into ethers
The Journal of Organic Chemistry
  • George A. Kraus, Iowa State University
  • Kevin A. Frazier, Iowa State University
  • Bruce D. Roth, Iowa State University
  • Michael J. Taschner, Iowa State University
  • Kent Neuenschwander, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
5-1-1981
DOI
10.1021/jo00324a050
Abstract
Although tetrahydrofurans and tetrahydropyrans are important structural subunits of many classes of natural products,l comparatively few general synthetic methods are known? Since y- and &lactones are readily available: an efficient and versatile transformation to the ether would significantly extend current methodology. The conversion of a lactone to an ether has been accomplished by hydride reduction to a diol followed by cyclization by way of a monotosylate4 or other activated ester.5
Comments

Reprinted (adapted) with permission from The Journal of Organic Chemistry, 46(11); 2414-2419. Doi: 10.1021/jo00324a050. Copyright 1981 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
George A. Kraus, Kevin A. Frazier, Bruce D. Roth, Michael J. Taschner, et al.. "Conversion of lactones into ethers" The Journal of Organic Chemistry Vol. 46 Iss. 11 (1981) p. 2417 - 2419
Available at: http://works.bepress.com/george_kraus/132/