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Article
Bridgehead intermediates in organic synthesis. A reproducible synthesis of adamantane-containing compounds
The Journal of Organic Chemistry
  • George A. Kraus, Iowa State University
  • Tiberiu M. Siclovan, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
2-1-1994
DOI
10.1021/jo00083a038
Abstract
Compounds containing the adamantane subunit have long been of interest to chemists due to the rigid structure and well-defined substitution chemistry of adamantane.l The discovery of the potent antiviral activity of amantadine (1-aminoadamantane) and rimantadine (a-methyl-l-adamantylmethylamine) has stimulated interest in the synthesis of adamantane-containing compounds.2 The significant neuroprotective properties of the NMDA antagonist memantine3 (l-amino-3,5-dimethyladamantane) have also prompted interest in adamantane synthesis
Comments

Reprinted (adapted) with permission from The Journal of Organic Chemistry, 59(4); 922-923. Doi: 10.1021/jo00083a038. Copyright 1994 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
George A. Kraus and Tiberiu M. Siclovan. "Bridgehead intermediates in organic synthesis. A reproducible synthesis of adamantane-containing compounds" The Journal of Organic Chemistry Vol. 59 Iss. 4 (1994) p. 922 - 923
Available at: http://works.bepress.com/george_kraus/128/