Synthesis of a modified anthracycline 4,6,9,11-tetradeoxydaunomycinoneThe Journal of Organic Chemistry
Publication VersionPublished Version
AbstractThe preparation of a tetradeoxy anthracyclinone is described. The key reaction is the cyclization of the acetylenic coumarin 10 to anthraquinone 11. Interestingly, the related model system 12 failed to cyclize. The transformation of 11 into the desired compound 13 was effected by straightforward reactions. The key intramolecular cyclization reaction is also useful for the preparation of phthalide quinone 7.
Copyright OwnerAmerican Chemical Society
Citation InformationGeorge A. Kraus and John O. Pezzanite. "Synthesis of a modified anthracycline 4,6,9,11-tetradeoxydaunomycinone" The Journal of Organic Chemistry Vol. 47 Iss. 22 (1982) p. 4337 - 4340
Available at: http://works.bepress.com/george_kraus/104/