Article
Internal validation of STRmix™ – A multi laboratory response to PCAST
Forensic Science International: Genetics
Document Type
Article
Publication Date
5-1-2018
Keywords
- PCAST,
- STRmix,
- Forensic DNA,
- Probabilistic genotyping,
- Continuous models,
- Validation
Disciplines
Abstract
We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.
ORCID ID
0000-0002-4931-5316
DOI
10.1016/j.fsigen.2018.01.003
Citation Information
Jo-Anne Bright, Rebecca Richards, Maarten Kruijver, Hannah Kelly, et al.. "Internal validation of STRmix™ – A multi laboratory response to PCAST" Forensic Science International: Genetics Vol. 34 (2018) p. 11 - 24 ISSN: 1872-4973 Available at: http://works.bepress.com/george-duncan/27/