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Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels
Chemical Communications (2014)
  • Declan Daly, Dr, Dublin City University
  • A Al-Sabi, Dr, Dublin City University
  • Gemma K Kinsella, Dr, National University of Ireland, Maynooth
  • Kieran Nolan, Dr, Dublin City University
  • J O Dolly, Prof, Dublin City University
Abstract

Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2–4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.

Publication Date
Winter November 18, 2014
Citation Information
Declan Daly, A Al-Sabi, Gemma K Kinsella, Kieran Nolan, et al.. "Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels" Chemical Communications Vol. 51 (2014)
Available at: http://works.bepress.com/gemma_kinsella/1/