Skip to main content
Article
Choosing the Right Path: Enhancement of Biologically Relevant Sets of Genes or Proteins Using Pathway Structure
Biology Faculty Publications
  • Reuben Thomas
  • Julia M. Gohlke
  • Geffrey F. Stopper, Sacred Heart University
  • Frederick M. Parham
  • Christopher J. Portier
Document Type
Article
Publication Date
1-1-2009
Abstract

A method is proposed that finds enriched pathways relevant to a studied condition using the measured molecular data and also the structural information of the pathway viewed as a network of nodes and edges. Tests are performed using simulated data and genomic data sets and the method is compared to two existing approaches. The analysis provided demonstrates the method proposed is very competitive with the current approaches and also provides biologically relevant results.

Comments

Originally published:

Thomas, Reuben, Geffrey Stopper et al. "Choosing the Right Path: Enhancement of Biologically Relevant Sets of Genes or Proteins Using Pathway Structure." Genome Biology 10.R44 (2009): R44.

(doi:10.1186/gb-2009-10-4-r44)

The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2009/10/4/R44

Citation Information
Reuben Thomas, Julia M. Gohlke, Geffrey F. Stopper, Frederick M. Parham, et al.. "Choosing the Right Path: Enhancement of Biologically Relevant Sets of Genes or Proteins Using Pathway Structure" (2009)
Available at: http://works.bepress.com/geffrey_stopper/1/