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Article
Simulation of Blood Flow and Nanoparticle Transport in a Stenosed Carotid Bifurcation and Pseudo-Arteriole
The Journal of Computational Multiphase Flows
  • Graham Doig, University of New South Wales
  • Guan H. Yeoh, University of New South Wales
  • Victoria Timchenko, University of New South Wales
  • Gary Rosengarten, University of New South Wales
  • Tracie J. Barber, University of New South Wales
  • Sherman C.P. Cheung, Royal Melbourne Institute of Technology
Publication Date
3-1-2012
Abstract
Numerical simulation of flow through a realistic bifurcated carotid artery geometry with a stenosis has been conducted for comparison to experimental measurements. The behaviour of simplified therapeutic nanoparticles in relatively low concentration was observed using a discrete particle approach. The role of size (diameters from 500 nm to 50 nm) in determining particle residence time and the potential for both desirable and undesirable wall interactions was investigated. It was found that mean particle residence time reduced with decreasing particle diameter, and the percentage of particles experiencing one or more wall interactions increased simultaneously. Further simulations were conducted on a scaled-down version of the geometry which approximated the size and flow conditions of an arteriole with capillary branches, and in this instance the mean residence time increased with decreasing particle diameter, owing largely to the greater influence of Brownian motion. 33% of all 50 nm particles were involved in wall interactions, indicating that smaller particles would have a greater ability to target, for instance, cancerous tumours in such regions.
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Citation Information
Graham Doig, Guan H. Yeoh, Victoria Timchenko, Gary Rosengarten, et al.. "Simulation of Blood Flow and Nanoparticle Transport in a Stenosed Carotid Bifurcation and Pseudo-Arteriole" The Journal of Computational Multiphase Flows Vol. 4 Iss. 1 (2012) p. 85 - 101
Available at: http://works.bepress.com/gcdoig/17/