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In vivo bioluminescent imaging (BLI): Noninvasive visualization and interrogation of biological processes in living animals
Sensors (2011)
  • Dan M. Close
  • Tingting Xu
  • Gary S. Sayler
  • Steven Ripp, University of Tennessee - Knoxville
Abstract

In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern biological research. This process, which involves the noninvasive interrogation of living animals using light emitted from luciferase-expressing bioreporter cells, has been applied to study a wide range of biomolecular functions such as gene function, drug discovery and development, cellular trafficking, protein-protein interactions, and especially tumorigenesis, cancer treatment, and disease progression. This article will review the various bioreporter/biosensor integrations of BLI and discuss how BLI is being applied towards a new visual understanding of biological processes within the living organism.

doi:10.3390/s110100180

Disciplines
Publication Date
2011
Citation Information
Dan M. Close, Tingting Xu, Gary S. Sayler and Steven Ripp. "In vivo bioluminescent imaging (BLI): Noninvasive visualization and interrogation of biological processes in living animals" Sensors Vol. 11 Iss. 1 (2011)
Available at: http://works.bepress.com/gary_sayler/4/