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Reporter proteins in whole-cell optical bioreporter detection systems, biosensor integrations, and biosensing applications
Sensors (2009)
  • Dan M. Close
  • Steven Ripp
  • Gary S. Sayler
Abstract

Whole-cell, genetically modified bioreporters are designed to emit detectable signals in response to a target analyte or related group of analytes. When integrated with a transducer capable of measuring those signals, a biosensor results that acts as a self-contained analytical system useful in basic and applied environmental, medical, pharmacological, and agricultural sciences. Historically, these devices have focused on signaling proteins such as green fluorescent protein, aequorin, firefly luciferase, and/or bacterial luciferase. The biochemistry and genetic development of these sensor systems as well as the advantages, challenges, and common applications of each one will be discussed.

doi:10.3390/s91109147

Disciplines
Publication Date
2009
Citation Information
Dan M. Close, Steven Ripp and Gary S. Sayler. "Reporter proteins in whole-cell optical bioreporter detection systems, biosensor integrations, and biosensing applications" Sensors Vol. 9 Iss. 11 (2009)
Available at: http://works.bepress.com/gary_sayler/15/