Trunk kinematics variables have been shown to be related to low back injury risk during lifting tasks and it was hypothesised that changes in hand-hold positions could influence trunk kinematics and thereby risk. Fourteen subjects lifted a 5 or 10 kg box using four different hand placement locations (two symmetric and two asymmetric) while their trunk kinematics (position, velocity and acceleration in the sagittal, coronal and transverse planes) were captured using the lumbar motion monitor (LMM). These kinematics data were then used to calculate the probability of high risk group membership (PHRGM) as defined in the LMM risk assessment model. The results showed significant effects of hand placement on trunk kinematics, resulting in significant changes in the PHRGM variable ranging from a low of 20% in a the symmetric low load condition to a high of 38% under the asymmetric, 10 kg condition.