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Article
Sex Differences in Endothelin-1-mediated Vasoconstrictor Tone in Middle-aged and Older Adults
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
  • Brian L Stauffer
  • Christian M Westby
  • Jared J Greiner
  • Gary P. Van Guilder
  • Christopher A Desouza
Document Type
Article
Publication Date
2-1-2010
Abstract
The prevalence of cardiovascular disease is lower in middle-aged and older women than men. Increased endothelin-1-mediated vasoconstriction has been linked to the etiology of a number of cardiovascular diseases, including atherosclerosis, heart failure, and hypertension. It is unknown whether a sex difference in endothelin-1-mediated vasoconstrictor tone exists in middle-aged and older adults. Therefore, we tested the hypothesis that middle-aged and older men would demonstrate greater ET-1-mediated vasoconstrictor tone than age-matched women. Forearm blood flow in response to intra-arterial infusions of endothelin (ET)-1, BQ-123 (a selective ET(A) receptor antagonist), and BQ-788 (a selective ET(B) receptor antagonist) was assessed by venous occlusion plethysmography in 21 women (age: 58 + or - 1 yr; body mass index: 26.0 + or - 1.0 kg/m(2)) and 25 men (age: 57 + or - 2 yr; body mass index: 26.8 + or - 0.7 kg/m(2)). In response to BQ-123, the increase in forearm blood flow from baseline was significantly higher in the men than the women (24 + or - 5% vs. 9 + or - 5%; P < 0.05). In contrast, the increase in forearm blood flow in response to BQ-123 coinfused with BQ-788 was greater in the women than the men, such that the maximum vasodilation to dual endothelin receptor blockade was similar between men and women (approximately 25%). There was no difference in the vasoconstrictor response to ET-1 between the sexes. These results indicate that middle-aged and older men are under greater ET(A) receptor-mediated vasoconstrictor tone than age-matched women. Since the ET(A) receptor is the predominant receptor subtype in the coronary vasculature, this sex difference in vasoconstrictor tone may be a mechanism contributing to the sex difference in the prevalence of coronary heart disease in middle-aged and older adults.
PMCID
PMC2828167
DOI of Published Version
10.1152/ajpregu.00626.2009
Publisher
American Physiological Society
Citation Information
Brian L Stauffer, Christian M Westby, Jared J Greiner, Gary P. Van Guilder, et al.. "Sex Differences in Endothelin-1-mediated Vasoconstrictor Tone in Middle-aged and Older Adults" American Journal of Physiology: Regulatory, Integrative and Comparative Physiology Vol. 298 Iss. 2 (2010) p. 261 - 265
Available at: http://works.bepress.com/gary-vanguilder/30/