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Article
Basal Endothelial Nitric Oxide Release is Preserved in Overweight and Obese Adults
Obesity Research
  • Christopher A DeSouza
  • Gary P. Van Guilder
  • Jared J Greiner
  • Derek T Smith
  • Greta L Hoetzer
  • Brian L Stauffer
Document Type
Article
Publication Date
8-1-2005
Abstract
OBJECTIVE: Impaired basal nitric oxide release is associated with a number of cardiovascular disorders including hypertension, arterial spasm, and myocardial infarction. We determined whether basal endothelial nitric oxide release is reduced in otherwise healthy overweight and obese adult humans.RESEARCH METHODS AND PROCEDURES: Seventy sedentary adults were studied: 32 normal weight (BMI/m(2)), 24 overweight (BMI > or = 25 < 30 kg/m(2)), and 14 obese (BMI > or = 30 kg/m(2)). Forearm blood flow (FBF) responses to intra-arterial infusions of N(g)-monomethyl-L-arginine (5 mg/min), a nitric oxide synthase inhibitor, were used as an index of basal nitric oxide release.RESULTS: N(g)-monomethyl-L-arginine elicited significant reductions in FBF in the normal weight (from 4.1 +/- 0.2 to 2.7 +/- 0.2 mL/100 mL tissue/min), overweight (4.1 +/- 0.1 to 2.8 +/- 0.2 mL/100 mL tissue/min), and obese (3.9 +/- 0.3 to 2.7 +/- 0.2 mL/100 mL tissue/min) subjects. Importantly, the magnitude of reduction in FBF (approximately 30%) was similar among the groups.DISCUSSION: These results indicate that the capacity of the endothelium to release nitric oxide under basal conditions is not compromised in overweight and obese adults.
Pages
6
Type
text
Format
application/pdf
Language
en
PMCID
PMC1361285
DOI of Published Version
10.1038/oby.2005.157
Publisher
North American Association for the Study of Obesity
Rights

In Copyright - Non-Commercial Use Permitted
http://rightsstatements.org/vocab/InC-NC/1.0/

Comments

This is the NIH Public Access Authors Manuscript. The Version of Record is published in Obesity Research. (2005);13(8). doi: 10.1038/oby.2005.157

Citation Information
Christopher A DeSouza, Gary P. Van Guilder, Jared J Greiner, Derek T Smith, et al.. "Basal Endothelial Nitric Oxide Release is Preserved in Overweight and Obese Adults" Obesity Research Vol. 13 Iss. 8 (2005) p. 1303 - 1306
Available at: http://works.bepress.com/gary-vanguilder/17/