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Article
Increased Arterial Stiffness in South Dakota American Indian Children
Applied Physiology, Nutrition, and Metabolism
  • Andrew M Litz
  • Gary P. Van Guilder, South Dakota State University
Document Type
Article
Publication Date
2-1-2016
Keywords
  • Adolescent,
  • Cardiovascular Diseases,
  • European Continental Ancestry Group,
  • Female,
  • Humans,
  • Indians,
  • North American,
  • Male,
  • Overweight,
  • Pediatric Obesity,
  • Risk Factors,
  • South Dakota,
  • Vascular Stiffness
Abstract
Arterial stiffness has been observed in white American obese children, yet there are no data in American Indian youth, who are affected disproportionately by the cardiovascular consequences of childhood obesity and its accompanying risk factors. The purpose of this study was to determine the association of childhood overweight-obesity and cardiometabolic risk factors with arterial stiffness in South Dakota white American and American Indian children. Thirty-six (28 white American and 8 American Indian) children (age, 13 ± 1 years; grades 6-8) from a rural South Dakota elementary and middle school were studied: 18 had a healthy weight (body mass index (BMI), 19.5 ± 1.9 kg/m(2)) and 18 were overweight-obese (BMI, 26.8 ± 3.5 kg/m(2)). Arterial stiffness was assessed using applanation tonometry via pulse wave analysis to determine carotid-radial pulse wave velocity (crPWV) and aortic augmentation index (AIx). There were no differences (P = 0.94) in crPWV between healthy weight (7.1 ± 1.4 m/s) and overweight-obese (7.3 ± 1.0 m/s) children, even after controlling for risk factors. However, crPWV was markedly elevated (P = 0.002) in overweight-obese American Indian children (7.7 ± 1.1 m/s) compared with white American children (6.8 ± 0.5 m/s), and these differences remained after controlling for blood pressure and more severe obesity in the American Indians. An obesity-matched subgroup analysis indicated that crPWV (7.7 ± 1.1 vs 6.8 ± 0.4 m/s) remained significantly greater in the American Indians (P = 0.03). There were no between-group differences in aortic AIx. These findings indicate an adverse influence of American Indian ethnicity on arterial stiffening in children with elevated adiposity. Arterial stiffness in American Indian children may accelerate early adulthood vascular disease.
DOI of Published Version
10.1139/apnm-2015-0426
Publisher
NRC
Citation Information
Andrew M Litz and Gary P. Van Guilder. "Increased Arterial Stiffness in South Dakota American Indian Children" Applied Physiology, Nutrition, and Metabolism Vol. 41 Iss. 2 (2016) p. 150 - 156
Available at: http://works.bepress.com/gary-vanguilder/13/