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Selected Works of Gary S. Goldberg
Article
Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative
Experimental Cell Research (1996)
  • Gary S. Goldberg, Rowan University School of Osteopathic Medicine
  • Alonso P. Moreno, State University of New York System
  • John F. Bechberger, University of Western Ontario
  • Stephen S. Hearn, Department of Pathology, St. Joseph's Health Centre, London, Ontario, Canada, N6A 5C1
  • Richard R. Shivers, University of Western Ontario
  • Daniel J. Macphee, University of Western Ontario
  • Yu Chun Zhang, University of Western Ontario
  • Christian C G Naus, University of Western Ontario
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Abstract
Glycyrrhetinic acid exhibits many pharmacological activities, including the ability to block gap junctional communication. However, the mechanism of glycyrrhetinic action is not clear. Others have shown that glycyrrhetinic acid apparently binds to a single proteinatious binding site in the plasma membrane. We present evidence that while exposure to glycyrrhetinic acid derivatives may not affect protein synthesis or location, it does seem to alter connexon particle packing in gap junction plaques.
Keywords
  • Carbenoxolone,
  • Cell Communication,
  • drug effects,
  • Connexin 43,
  • Gap Junctions,
  • Glioma,
  • Glycyrrhetinic Acid,
  • Isoquinolines,
  • Succinates,
  • pharmacology,
  • Tumor Cells
Disciplines
Publication Date
January 1, 1996
DOI
10.1006/excr.1996.0006
Citation Information
Gary S. Goldberg, Alonso P. Moreno, John F. Bechberger, Stephen S. Hearn, et al.. "Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative" Experimental Cell Research Vol. 222 Iss. 1 (1996) p. 48 - 53 ISSN: 0014-4827
Available at: http://works.bepress.com/gary-s-goldberg/27/