Skip to main content
Intranasal ketamine for anesthetic premedication in children: a systematic review.
Pain Management
  • Naveen Poonai, Western University
  • Kyle Canton, Western University
  • Samina Ali
  • Shawn Hendrikx, Western University
  • Amit Shah, Western University
  • Michael Miller, Western University
  • Gary Joubert, Western University
  • Lisa Hartling
Document Type
Publication Date
URL with Digital Object Identifier


In children, intravenous anesthetic premedication can be distressing. Intranasal (IN) ketamine offers a less invasive approach.

Materials and Methods

We included randomized trials of IN ketamine in anesthetic premedication in children 0-19 years. We performed electronic searches of MEDLINE, EMBASE, Google Scholar, CINAHL, Cochrane Library, Web of Science, Scopus, clinical trial registries and conference proceedings.


Among the 23 trials (n = 1680) included, IN ketamine adequately sedated 220/311 (70%) for face mask application, 217/308 (70%) for caregiver separation, 200/371 (54%) for iv. insertion and 19/30 (63%) for monitor application. Vomiting was the most common adverse effect (35/1579 [2.2%]).


There is a need for sufficiently powered, methodologically rigorous trials, using psychometrically evaluated, objective outcome measures to meaningfully inform practice.


Article available at Pain Management, Vol. 8(6), pp. 495-503.

Citation Information
Naveen Poonai, Kyle Canton, Samina Ali, Shawn Hendrikx, et al.. "Intranasal ketamine for anesthetic premedication in children: a systematic review." Pain Management Vol. 8 Iss. 6 (2018) p. 495 - 503
Available at: