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Presentation
Abstract: R5.00006 : Interictal to Ictal Phase Transition in a Small-World Network
Bulletin of the American Physical Society Volume 62 Number 4
  • Louis R. Nemzer, Nova Southeastern University
  • Gary D. Cravens, Nova Southeastern University
  • Robert Worth, Indiana University
Event Name/Location
American Physical Society March Meeting, New Orleans, Louisiana, March 13-17, 2017
Document Type
Conference Proceeding
Publication Date
3-16-2017
Abstract

Real-time detection and prediction of seizures in patients with epilepsy is essential for rapid intervention. Here, we perform a full Hodgkin-Huxley calculation using n ≈ 50 \textit{in silico} neurons configured in a small-world network topology to generate simulated EEG signals. The connectivity matrix, constructed using a Watts--Strogatz algorithm, admits randomized or deterministic entries. We find that situations corresponding to interictal (non-seizure) and ictal (seizure) states are separated by a phase transition that can be influenced by congenital channelopathies, anticonvulsant drugs, and connectome plasticity. The interictal phase exhibits scale-free phenomena, as characterized by a power law form of the spectral power density, while the ictal state suffers from pathological synchronization. We compare the results with intracranial EEG data and show how these findings may be used to detect or even predict seizure onset. Along with the balance of excitatory and inhibitory factors, the network topology plays a large role in determining the overall characteristics of brain activity. We have developed a new platform for testing the conditions that contribute to the phase transition between non-seizure and seizure states.

Citation Information
Louis R. Nemzer, Gary D. Cravens and Robert Worth. "Abstract: R5.00006 : Interictal to Ictal Phase Transition in a Small-World Network" Bulletin of the American Physical Society Volume 62 Number 4 (2017)
Available at: http://works.bepress.com/gary-cravens/1/