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Selected Works of Ganesh Halade
Contribution to Book
Cardiac Wound Healing Post-Myocardial Infarction: a Novel Method to Target Extracellular Matrix Remodeling in the Left Ventricle
Wound Regeneration and Repair. Methods in Molecular Biology (Methods and Protocols)
  • Rogelio Zamilpa, University of Texas Health Science Center at San Antonio
  • Jianhua Zhang, University of Texas Health Science Center at San Antonio
  • Ying Ann Chiao, University of Texas Health Science Center at San Antonio
  • Lisandra E. De Castro Brás, University of Texas Health Science Center at San Antonio
  • Ganesh V. Halade, University of Texas Health Science Center at San Antonio
  • Yonggang Ma, University of Texas Health Science Center at San Antonio
  • Sander O. Hacker, University of Texas Health Science Center at San Antonio
  • Merry L. Lindsey, University of Texas Health Science Center at San Antonio
Link
Document Type
Book Chapter
Publication Date
1-1-2013
Keywords
  • Cardiac wound healing,
  • Decellularization,
  • Extracellular matrix,
  • Inflammation,
  • Matrix metalloproteinases,
  • Mice,
  • Myocardial infarction
Digital Object Identifier (DOI)
https://doi.org/10.1007/978-1-62703-505-7_18
Abstract

Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the left anterior descending coronary artery (LAD) is a commonly used surgical model to study post-MI effects in mice. LAD occlusion induces a robust wound healing response that includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in the left ventricle following surgically induced MI in mice.

Citation / Publisher Attribution
Cardiac Wound Healing Post-Myocardial Infarction: a Novel Method to Target Extracellular Matrix Remodeling in the Left Ventricle, in R. Gourdie & T. Myers (Eds.), Wound Regeneration and Repair. Methods in Molecular Biology (Methods and Protocols), Springer, v. 1037, p. 313-324
Citation Information
Rogelio Zamilpa, Jianhua Zhang, Ying Ann Chiao, Lisandra E. De Castro Brás, et al.. "Cardiac Wound Healing Post-Myocardial Infarction: a Novel Method to Target Extracellular Matrix Remodeling in the Left Ventricle" Wound Regeneration and Repair. Methods in Molecular Biology (Methods and Protocols) Vol. 1037 (2013) p. 313 - 324
Available at: http://works.bepress.com/ganesh-halade/5/