Article
Elevation in analgetic effect and plasma levels of morphine by desipramine in rats
Pain
Document Type
Article
Publication Date
1-1-1982
Disciplines
Abstract
Pretreatment of rats with desipramine (30 mg/kg, s.c.) enhanced both peak intensity and duration of morphine sulfate (5 mg/kg s.c.) analgesia as determined by measurement of tail flick latency. Morphine concentrations in plasma were also significantly elevated after desipramine. Increased narcotic analgetic responses following desipramine pretreatment appear related to higher circulating levels of unmetabolized morphine. © 1982.
Citation Information
Frederick J. Goldstein, P. Mojaverian, M. Ossipov and B. N. Swanson. "Elevation in analgetic effect and plasma levels of morphine by desipramine in rats" Pain Vol. 14 Iss. 3 (1982) p. 279 - 282 Available at: http://works.bepress.com/frederick_goldstein/39/
This article was published in Pain, Volume 14, Issue 3, Pages 279-282.
The published version is available at http://dx.doi.org/10.1016/0304-3959(82)90134-8.Copyright © 1982.