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Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
Molecular and Cellular Oncology
  • Charles A. Ishak, London Regional Cancer Program
  • Frederick A. Dick, London Regional Cancer Program
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Recent work demonstrates that retention of a single functional retinoblastoma susceptibility (RB1) allele is insufficient to maintain genome stability. Haploinsufficiency of RB1 accelerates cancer pathogenesis in concert with inactivation of tumor protein p53. Collectively, multiple lines of evidence suggest revision of the ‘2-hit’ model to include conditional haploinsufficiency of RB1.

Citation Information
Charles A. Ishak and Frederick A. Dick. "Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene" Molecular and Cellular Oncology Vol. 2 Iss. 1 (2015)
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