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Article
An Rb-condensin II complex mediates long-range chromosome interactions and influences expression at divergently paired genes
Molecular and Cellular Biology
  • Aren E. Marshall, Lawson Health Research Institute
  • Charles A. Ishak, Lawson Health Research Institute
  • Frederick A. Dick, Lawson Health Research Institute
Document Type
Article
Publication Date
1-1-2020
URL with Digital Object Identifier
10.1128/MCB.00452-19
Abstract

Interphase chromosomes are organized into topologically associated domains in order to establish and maintain integrity of transcriptional programs that remain poorly understood. Here, we show that condensin II and TFIIIC are recruited to bidirectionally transcribed promoters by a mechanism that is dependent on the retinoblastoma (RB) protein. Long-range chromosome contacts are disrupted by loss of condensin II loading, which leads to altered expression at bidirectional gene pairs. This study demonstrates that mammalian condensin II functions to organize long-range chromosome contacts and regulate transcription at specific genes. In addition, RB dependence of condensin II suggests that widespread misregulation of chromosome contacts and transcriptional alterations are a consequence of RB mutation.

Citation Information
Aren E. Marshall, Charles A. Ishak and Frederick A. Dick. "An Rb-condensin II complex mediates long-range chromosome interactions and influences expression at divergently paired genes" Molecular and Cellular Biology Vol. 40 Iss. 2 (2020)
Available at: http://works.bepress.com/frederick-dick/3/