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About Frank Vrionis

Frank Vrionis, M.D., is the medical director of Marcus Neuroscience Institute, established at Boca Raton Regional Hospital, part of Baptist Health. Dr. Vrionis specializes in treating brain, skull base and spine tumors. He has extensive experience in minimally invasive spine surgery, brain tumor surgery, skull base surgery, vascular neurosurgery and poliovirus treatment of brain tumors.
Prior to joining Marcus Neuroscience Institute in 2016, Dr. Vrionis spent 17 years at the H. Lee Moffitt Cancer Center.
Active in research, Dr. Vrionis described for the first time the presence of cancer stem cells in malignant brain tumors and established through a clinical trial the role of vertebroplasty for spine fractures in cancer patients.
Dr. Vrionis serves as a professor of surgery at the Charles E. Schmidt College of Medicine at Florida Atlantic University. 
Dr. Vrionis’ approach to patient care is to treat each patient with love and respect, as he would a member of his own family. When he is not treating patients, he enjoys spending time in nature, farming, traveling, reading about philosophy and skiing.


October 2016 - Present Chairman, Department of Neurosurgery, Baptist Health South Florida Boca Raton Regional Hospital
October 2016 - Present Director, Baptist Health South Florida Marcus Neuroscience Institute
October 2016 - Present Professor of Surgery, Florida Atlantic University ‐ Charles E. Schmidt College of Medicine
January 2011 - 2016 Chief of Neurosurgery, H. Lee Moffitt Cancer Center
March 2009 - 2016 Professor, Departments of Oncologic Sciences, University of South Florida ‐ College of Medicine
July 2007 - 2016 Director and Founder, Spine Oncology Fellowship Program, H. Lee Moffitt Cancer Center
June 2009 - 2015 Director and Founder, Spine Research Laboratory, H. Lee Moffitt Cancer Center
June 2003 - 2009 Associate Professor of Neurosurgery, Orthopedic Surgery & Oncology, University of South Florida ‐ College of Medicine
October 1999 - May 2003 Assistant Professor of Neurosurgery Otolaryngology, Head & Neck Surgery, University of South Florida ‐ College of Medicine
October 1999 - April 2000 Chief of Neurosurgery, James A. Haley Veterans Administration Hospital
July 1997 - October 1999 Assistant Professor, Departments of Neurosurgery, Anatomy and Neurobiology, University of Tennessee ‐ College of Medicine
July 1997 - October 1999 Director and Founder, Human Brain Tumor Research Laboratory, University of Tennessee
July 1997 - October 1999 Neurosurgical Associate, Semmes-Murphey Clinic

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Professional Service and Affiliations

1999 - Present Member, North American Spine Society
1993 - Present Member, American Association of Neurological Surgeons
1991 - Present Member, Congress of Neurological Surgeons
2005 - 2016 Member, AO North America
1998 - 2016 Member, Neuro-Oncology Society
2007 - 2009 Member, American Academy of Spine Physicians
1999 - 2009 Member, North American Skull Base Society
2001 - 2007 Member, Florida Neurosurgical Society
1999 - 2005 Member, American Cancer Research Association
1997 - 2004 Member, Joint Section on Tumors of the AANS and CNS
1987 - 2000 Member, Harvard Alumni Association
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Honors and Awards

  • 02/2013 Physician of the Year H. Lee Moffitt Cancer Center
  • 02/2009 Certificate of Appreciation 2nd Annual Perioperative Nursing Multidisciplinary Conference H. Lee Moffitt Cancer Center
  • 2007-2008 Listed in the “Guide to America’s Top Surgeons”
  • 01/2007 United Health Premium Quality and Efficiency of Care (two star) Designation for Spine Surgery
  • 1995 Recipient of the Fellowship Aware from the Congress of Neurological Surgeons ($10,000)
  • 09/1994 Brain Tumor Society Aware, “Mechanisms related to the bystander cytocidal effect and the role of the bystander effect in the treatment of meningeal neoplasia”
  • 05/1993 Brain Tumor Society Award, “Retroviral vector gene therapy in a rat model of neoplastic meningitis”
  • 1986-1990 Graduate fellowship, Duke University
  • 1986 Obtained M.P.H. degree from Harvard University with highest honors
  • 1983 Graduated 2nd in rank among 91 medical students
  • 11/1977 Honorary Scholarship upon entering medical school
  • 1976 Saris Foundation Scholarship in Chemistry and Physics
  • 1972 Athens Mayor’s medal for excellence in studies


1991 - 1997 Residency Program - Neurosurgery, Tufts University ‐ Department of Neurosurgery
1995 - 1996 Fellowship Program - Skull-base Surgery, University of Tennessee ‐ Semmes-Murphey Clinic and Department of Neurosurgery
1990 - 1991 Internship, Tufts University ‐ Department of Surgery
1986 - 1990 Tumor Immunology, Ph.D., Duke University
1985 - 1986 Public Health, M.P.H., Harvard University
1977 - 1984 Doctor of Medicine, M.D., University of Athens ‐ School of Medicine

Contact Information

Marcus Neuroscience Institute
800 Meadows Road
Boca Raton, FL 33486
(561) 955-4600

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