Approximately fifteen million Muslims live and work in the United States of America. Most of these Muslims are American by birth; yet some confront discrimination, harassment, and retaliation in the workplace because of their religion. Religious discrimination is illegal in the workplace in the United States pursuant to civil rights laws. This article examines the most common challenges that American Muslims face in the workplace. The article then offers pertinent recommendations to organizational leaders so they not only can fulfill their legal duties, but also attract and retain the most qualified workers regardless of their religious affiliations, beliefs, observances, and practices.