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Genetic deletion of interleukin-15 is not associated with major structural changes following experimental post-traumatic knee osteoarthritis in rats
Applied Sciences (Switzerland)
  • Ermina Hadzic, Schulich School of Medicine & Dentistry
  • Garth Blackler, Schulich School of Medicine & Dentistry
  • Holly Dupuis, Schulich School of Medicine & Dentistry
  • Stephen James Renaud, Schulich School of Medicine & Dentistry
  • Christopher Thomas Appleton, Schulich School of Medicine & Dentistry
  • Frank Beier, Schulich School of Medicine & Dentistry
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Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity and may perpetuate inflammation following joint trauma. Interleukin-15 (IL-15), a pro-inflammatory cytokine, is increased in OA patients, although its roles in PTOA pathophysiology are not well characterized. Here, we utilized Il15 deficient rats to examine the role of IL-15 in PTOA pathogenesis in an injury-induced model. OA was surgically induced in Il15 deficient Holtzman Sprague-Dawley rats and control wild-type rats to compare PTOA progression. Semi-quantitative scoring of the articular cartilage, subchondral bone, osteo-phyte size, and synovium was performed by two blinded observers. There was no significant difference between Il15 deficient rats and wild-type rats following PTOA-induction across articular cartilage damage, subchondral bone damage, and osteophyte scoring. Similarly, synovitis scoring across six parameters found no significant difference between genetic variants. Overall, IL-15 does not appear to play a key role in the development of structural changes in this surgically-induced rat model of PTOA.

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Hadzic, E.; Blackler, G.; Dupuis, H.; Renaud, S.J.; Appleton, C.T.; Beier, F. Genetic Deletion of Interleukin-15 Is Not Associated with Major Structural Changes Following Experimental Post-Traumatic Knee Osteoarthritis in Rats. Appl. Sci. 2021, 11, 7118.