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Article
Adjuvant CCNU (Lomustine) and Prednisone Chemotherapy for Dogs With Incompletely Excised Grade 2 Mast Cell Tumors
Journal of the American Animal Hospital Association
  • Kenji Hosoya
  • William C. Kisseberth
  • Francisco J. Alvarez, Wright State University - Main Campus
  • Ana Lara-Garcia
  • Gillian Beamer
  • Paul C. Stromberg
  • C. Guillermo Couto
Document Type
Article
Publication Date
1-1-2009
Abstract
The use of adjuvant 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; lomustine) to treat incompletely excised canine mast cell tumors (MCTs) has not been evaluated. Medical records of 12 dogs with grade 2 MCT treated with incomplete surgical excision and adjuvant CCNU and prednisone chemotherapy were reviewed. Local recurrence rate, metastasis rate, and survival time were evaluated. None of the dogs developed local recurrence or regional/ distant metastases. Two dogs developed fatal liver failure. The 1- and 2-year progression-free rates of surviving dogs were 100% and 77%, respectively. Postoperative adjuvant CCNU appears to be a useful alternative to radiation therapy for incompletely excised canine cutaneous MCTs.
Citation Information
Kenji Hosoya, William C. Kisseberth, Francisco J. Alvarez, Ana Lara-Garcia, et al.. "Adjuvant CCNU (Lomustine) and Prednisone Chemotherapy for Dogs With Incompletely Excised Grade 2 Mast Cell Tumors" Journal of the American Animal Hospital Association Vol. 45 Iss. 1 (2009) p. 14 - 18 ISSN: 0587-2871
Available at: http://works.bepress.com/francisco_alvarez/91/