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The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative Stress
Research Day
  • Tashinea Lee, Philadelphia College of Osteopathic Medicine
  • Francis E. Jenney, Philadelphia College of Osteopathic Medicine
Location
Georgia Campus
Start Date
2-5-2012 2:00 PM
End Date
2-5-2012 4:00 PM
Description

Background: Hospital acquired infections due to Clostridium difficile (C. diff) is associated with nosocomial diarrhea and pseudomembranous colitis. Using a published microarray analysis of C. diff strain 630, several open reading frames (ORFs) were noted for their upregulation under different environmental stresses. One of these genes (CD1134) is a putative glyoxalase I. The glyoxalase enzymes detoxify a side product of glycolysis, methylglyoxal, and use metals as a cofactor.

Citation Information
Tashinea Lee and Francis E. Jenney. "The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative Stress" (2012)
Available at: http://works.bepress.com/francis_jenney/8/