The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative StressResearch Day
Start Date2-5-2012 2:00 PM
End Date2-5-2012 4:00 PM
DescriptionBackground: Hospital acquired infections due to Clostridium difficile (C. diff) is associated with nosocomial diarrhea and pseudomembranous colitis. Using a published microarray analysis of C. diff strain 630, several open reading frames (ORFs) were noted for their upregulation under different environmental stresses. One of these genes (CD1134) is a putative glyoxalase I. The glyoxalase enzymes detoxify a side product of glycolysis, methylglyoxal, and use metals as a cofactor.
Citation InformationTashinea Lee and Francis E. Jenney. "The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative Stress" (2012)
Available at: http://works.bepress.com/francis_jenney/8/