Due to their multiple minoritized identities, Latinx sexual- and gender-minority immigrants risk exposure to various forms of traumatic stressors at home and abroad that can result in post-traumatic stress disorder and other comorbid problems like depression. A much-needed review and synthesis of the latest research highlights important factors for practitioners and scholars to consider relevant to this vulnerable and under researched population. A data-driven conceptualization helps identify risk factors across different points in time such as violence and discrimination from communal and institutional sources as well as acculturative and minority stressors. Gender can heighten the risk for victimization. Response factors to consider include social support and coping, trauma-informed interventions, and access to culturally competent integrative care.